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HMGBiotech 高遷移率蛋白、質(zhì)粒、抗體-相關(guān)技術(shù)文章

更新時(shí)間:2024-07-20      瀏覽次數(shù):163

HMGBiotech  高遷移率蛋白、質(zhì)粒、抗體

 

HMGBiotech公司簡(jiǎn)介

HMGBiotech公司研發(fā)的HMGB 1是細(xì)胞核的一個(gè)組成部分,在基因組的組織和表達(dá)中具有多種功能。HMG生物技術(shù)SRL為活躍在這一領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法。它還有助于比安奇實(shí)驗(yàn)室開發(fā)分析和試劑。

HMGBiotech是一家生物技術(shù)公司,由HMGB領(lǐng)域的 ling xian 科學(xué)家Marco E. Bianchi創(chuàng)立。

HMGBiotech是唯yi一家生產(chǎn)HMGB1質(zhì)量控制氧化還原變體的生產(chǎn)商。 該公司為活躍于這一有前途領(lǐng)域的其他研究人員和公司提供試劑、服務(wù)和想法,并幫助 Bianchi 實(shí)驗(yàn)室開發(fā)檢測(cè)方法和試劑。

HMGB1是細(xì)胞核的一個(gè)組成部分,在基因組的組織和表達(dá)中具有多種功能。當(dāng)細(xì)胞因損傷(病毒、機(jī)械或化學(xué)創(chuàng)傷、中毒)而死亡時(shí),HMGB1 被釋放并被附近細(xì)胞中的受體吸收。此外,處于嚴(yán)重壓力下的細(xì)胞甚至在死亡前就會(huì)分泌HMGB1。存活的細(xì)胞會(huì)發(fā)出一線反應(yīng) - 炎癥 - 并試圖替換死細(xì)胞并重建受損組織。HMGB1 促進(jìn)恢復(fù)和再生,例如梗死后心臟的恢復(fù)和再生。然而,過多的 HMGB1 與膿毒癥(過度炎癥導(dǎo)致急性痛苦并最終死亡)、關(guān)節(jié)炎、動(dòng)脈粥樣硬化和癌癥轉(zhuǎn)移有關(guān)。

anti HMGB1單克隆抗體

小鼠單克隆 IgG1 DPH1.1 是通過向 C57BL/6 小鼠注射 17 聚體肽 P1 KGKPDAAKKGVVKAEKS) 產(chǎn)生的。雜交瘤通過標(biāo)準(zhǔn)技術(shù)從脾細(xì)胞中產(chǎn)生,并通過 ELISA 針對(duì)免疫原和全長(zhǎng) HMGB1 進(jìn)行測(cè)試。

DPH1.1 mAb 可識(shí)別所有哺乳動(dòng)物 HMGB1,包括人、小鼠和大鼠。無法識(shí)別 HMGB2。

DPH1.1 mAb 可用于蛋白質(zhì)印跡 (WB)。

DPH1.1 mAb 在跨孔遷移試驗(yàn)中阻斷 HMGB1 誘導(dǎo)的細(xì)胞遷移。

在體內(nèi),靜脈內(nèi)施用 DPH1.1 mAb 220 μg/小鼠) 可阻斷炎癥細(xì)胞募集到壞死和感染部位。

本產(chǎn)品僅供研究使用,不能用于人體。

 

HMGBiotech公司熱銷產(chǎn)品

產(chǎn)品名稱

貨號(hào)

規(guī)格

100 ug Fully reduced HMGB1, LPS free

HM-115

100 ug

50 ug Fully reduced HMGB1, LPS free

HM-116

50 ug

100 ug Disulfide HMGB1, LPS free

HM-121

100 ug

100 ug BoxA from HMGB1, LPS-free and tested in migration assay

HM-012

100 ug

50 ug Disulfide HMGB1, LPS free

HM-122

50 ug

500 ug BoxA from HMGB1, LPS-free and tested in migration assay

HM-013

500 ug

1 mg HMGB1 for biochemistry

HM-100

1 mg

2.5 mg BoxA from HMGB1, LPS-free and tested in migration assay

HM-014

2.5 mg

250 ug HMGB1 biochemistry

HM-101

250 ug

25 ug BoxA from HMGB1, LPS-free and tested in migration assay

HM-011

25 ug

15 ug BoxB from HMGB1, LPS-free and tested in migration assay

HM-053

15 ug

15 ug Fully reduced HMGB1, LPS free

HM-117

15 ug

10 ug Disulfide HMGB1, LPS free

HM-123

10 ug

15 ug Non-oxidizable HMGB1, LPS free

HM-133

15 ug

250 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in   migration

HM-170

250 ug

100 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in   migration

HM-171

100 ug

50 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in   migration

HM-172

50 ug

15 ug Stromal Cell-Derived Factor 1α (SDF-1α, CXCL12) tested in   migration

HM-173

15 ug

50 ug HMGB1 15N labelled for Mass Spectrometry

HM-180

50 ug

5 ug HMGB1 15N labelled for Mass Spectrometry

HM-181

5 ug

2.5 mg BoxA 2D from HMGB1, LPS-free and tested in migration assay

HM-190

2.5 mg

500 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay

HM-191

500 ug

100 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay

HM-192

100 ug

25 ug BoxA 2D from HMGB1, LPS-free and tested in migration assay

HM-193

25 ug

Control cell lysates from Hmgb1 +/+

HM-001

請(qǐng)咨詢

Control cell lysates from Hmgb1 -/-

HM-002

請(qǐng)咨詢

1 mg BoxB from HMGB1, LPS-free and tested in migration assay

HM-050

1 mg

250 ug BoxB from HMGB1, LPS-free and tested in migration assay

HM-051

250 ug

100 ug BoxB from HMGB1, LPS-free and tested in migration assay

HM-052

100 ug

500 ug Fully reduced HMGB1, LPS free

HM-114

500 ug

250 ug Disulfide HMGB1, LPS free

HM-120

250 ug

500 ug Non-oxidizable HMGB1, LPS free

HM-130

500 ug

100 ug Non-oxidizable HMGB1, LPS free

HM-131

100 ug

50 ug Non-oxidizable HMGB1, LPS free

HM-132

50 ug

500 ug HMGB2, LPS-free and tested in migration assay

HM-151

500 ug

100 ug HMGB2, LPS-free and tested in migration assay

HM-152

100 ug

50 ug HMGB2, LPS-free and tested in migration assay

HM-153

50 ug

Embryonic fibroblasts immortalized with large T antigen. One vial of   -/- cells and one vial of +/+ cells

HM-201

2

Embryonic fibroblasts immortalized with the 3T3 method. One vial of -/-   cells and one vial of +/+ cells

HM-221

2

Embryonic fibroblasts, Hmgb1-/- and HMGB2-low, immortalized with the   3T3 method. One vial of cells, and

HM-223

2

HMGB1 Isoforms Kit - Test size

HM-030

請(qǐng)咨詢

Embryonic fibroblasts immortalized with the 3T3 method. One vial of   Hmgb2-/- cells and one vial of +/+ cells

HM-251

2

HMGB1 Isoforms Kit - Regular size

HM-031

請(qǐng)咨詢

20 ug p-mHMG1

HM-300

20 ug

50 ug Terminally oxidized HMGB1, LPS free

HM-062

50 ug

20 ug p-mHMG1tag

HM-301

20 ug

100 ug Terminally oxidized HMGB1, LPS free

HM-061

100 ug

20 ug pEGFP-HMGB1

HM-302

20 ug

250 ug Terminally oxidized HMGB1, LPS free

HM-060

250 ug

20 ug pcDNA/FL-RAGE plasmid

HM-310

20 ug

 


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